What should be used to attach plywood to a framed wall when the edges do not align with the studs?

When attaching plywood to a framed wall, especially when the edges of the plywood do not line up with the studs, toggle bolts are the most effective choice. Toggle bolts are designed to anchor along a hollow wall or panel, providing a secure fastening method where there are no direct studs to support the weight of the plywood.

The mechanism of toggle bolts involves a metal wing that opens up once inserted into the wall, creating a larger surface area against the back of the wall material, which helps distribute the load more evenly. This is particularly important with plywood, as it can have significant weight, and ensuring a solid attachment prevents sagging or separation over time.

In scenarios where studs are not accessible, attempting to use wood screws or nails may not provide adequate support since they require a stud for optimal holding power. Similarly, while other types of anchors can be helpful, toggle bolts are generally superior for heavier applications like plywood in typical wall assemblies found in many buildings.